Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-to-in vivo predictions of hepatic clearance

Predictions of xenobiotic hepatic clearance in humans using in vitro-to-in vivo extrapolation methods are frequently inaccurate and problematic. Multiple strategies are being pursued to disentangle responsible mechanisms. The objective of this work is to evaluate the feasibility of using insights ga...

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Detalles Bibliográficos
Autores principales: Krishnan, Preethi, Smith, Andrew K., Ropella, Glen E. P., Dutta, Lopamudra, Kennedy, Ryan C., Hunt, C. Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307204/
https://www.ncbi.nlm.nih.gov/pubmed/35867653
http://dx.doi.org/10.1371/journal.pone.0269775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307204/
https://www.ncbi.nlm.nih.gov/pubmed/35867653
http://dx.doi.org/10.1371/journal.pone.0269775

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