Cloning and base editing of GFP transgenic rhesus monkey and off-target analysis

We report the cloning of a 12-year-old transgenic green fluorescent protein (GFP) monkey by somatic cell nuclear transfer (SCNT) and base editing of the embryos, accompanied with safety evaluation of adenine base editors (ABEs). We first show the ability of ABEmax to silence GFP through A-to-G editi...

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Detalles Bibliográficos
Autores principales: Kang, Yu, Dai, Shaoxing, Zeng, Yuqiang, Wang, Fang, Yang, Pengpeng, Yang, Zhaohui, Pu, Youwei, Li, Zifan, Chen, Xinglong, Tian, Baohong, Si, Wei, Ji, Weizhi, Niu, Yuyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307242/
https://www.ncbi.nlm.nih.gov/pubmed/35867792
http://dx.doi.org/10.1126/sciadv.abo3123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307242/
https://www.ncbi.nlm.nih.gov/pubmed/35867792
http://dx.doi.org/10.1126/sciadv.abo3123

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