β2-subunit alternative splicing stabilizes Cav2.3 Ca(2+) channel activity during continuous midbrain dopamine neuron-like activity

In dopaminergic (DA) Substantia nigra (SN) neurons Cav2.3 R-type Ca(2+)-currents contribute to somatodendritic Ca(2+)-oscillations. This activity may contribute to the selective degeneration of these neurons in Parkinson’s disease (PD) since Cav2.3-knockout is neuroprotective in a PD mouse model. He...

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Detalles Bibliográficos
Autores principales: Siller, Anita, Hofer, Nadja T, Tomagra, Giulia, Burkert, Nicole, Hess, Simon, Benkert, Julia, Gaifullina, Aisylu, Spaich, Desiree, Duda, Johanna, Poetschke, Christina, Vilusic, Kristina, Fritz, Eva Maria, Schneider, Toni, Kloppenburg, Peter, Liss, Birgit, Carabelli, Valentina, Carbone, Emilio, Ortner, Nadine Jasmin, Striessnig, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307272/
https://www.ncbi.nlm.nih.gov/pubmed/35792082
http://dx.doi.org/10.7554/eLife.67464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307272/
https://www.ncbi.nlm.nih.gov/pubmed/35792082
http://dx.doi.org/10.7554/eLife.67464

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