Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans

RNA-guided RNA-targeting nucleases, such as CRISPR–Cas13 proteins, have therapeutic potential for gene editing. Among Cas13d enzymes, Cas13d from the bacteria Ruminococcus flavefaciens (RfxCas13d) is of particular interest owing to its small size and high specificity. However, the existence of pre-e...

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Detalles Bibliográficos
Autores principales: Tang, Xin-Zi Emily, Tan, Shu Xuan, Hoon, Shawn, Yeo, Gene W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307479/
https://www.ncbi.nlm.nih.gov/pubmed/35668177
http://dx.doi.org/10.1038/s41591-022-01848-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307479/
https://www.ncbi.nlm.nih.gov/pubmed/35668177
http://dx.doi.org/10.1038/s41591-022-01848-6

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