Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

Clonal hematopoiesis of indeterminate potential (CHIP) increases rapidly in prevalence beyond age 60 and has been associated with increased risk for malignancy, heart disease and ischemic stroke. CHIP is driven by somatic mutations in hematopoietic stem and progenitor cells (HSPCs). Because mutation...

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Detalles Bibliográficos
Autores principales: Robertson, Neil A., Latorre-Crespo, Eric, Terradas-Terradas, Maria, Lemos-Portela, Jorge, Purcell, Alison C., Livesey, Benjamin J., Hillary, Robert F., Murphy, Lee, Fawkes, Angie, MacGillivray, Louise, Copland, Mhairi, Marioni, Riccardo E., Marsh, Joseph A., Harris, Sarah E., Cox, Simon R., Deary, Ian J., Schumacher, Linus J., Kirschner, Kristina, Chandra, Tamir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307482/
https://www.ncbi.nlm.nih.gov/pubmed/35788175
http://dx.doi.org/10.1038/s41591-022-01883-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307482/
https://www.ncbi.nlm.nih.gov/pubmed/35788175
http://dx.doi.org/10.1038/s41591-022-01883-3

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