NUPR1 protects against hyperPARylation-dependent cell death

Proteomic, cellular and biochemical analysis of the stress protein NUPR1 reveals that it binds to PARP1 into the nucleus and inhibits PARP1 activity in vitro. Mutations on residues Ala33 or Thr68 of NUPR1 or treatment with its inhibitor ZZW-115 inhibits this effect. PARylation induced by 5-fluoroura...

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Detalles Bibliográficos
Autores principales: Santofimia-Castaño, Patricia, Huang, Can, Liu, Xi, Xia, Yi, Audebert, Stephane, Camoin, Luc, Peng, Ling, Lomberk, Gwen, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307593/
https://www.ncbi.nlm.nih.gov/pubmed/35869257
http://dx.doi.org/10.1038/s42003-022-03705-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307593/
https://www.ncbi.nlm.nih.gov/pubmed/35869257
http://dx.doi.org/10.1038/s42003-022-03705-1

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