Altered tRNA dynamics during translocation on slippery mRNA as determinant of spontaneous ribosome frameshifting

When reading consecutive mRNA codons, ribosomes move by exactly one triplet at a time to synthesize a correct protein. Some mRNA tracks, called slippery sequences, are prone to ribosomal frameshifting, because the same tRNA can read both 0- and –1-frame codon. Using smFRET we show that during EF-G-c...

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Detalles Bibliográficos
Autores principales: Poulis, Panagiotis, Patel, Anoshi, Rodnina, Marina V., Adio, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307594/
https://www.ncbi.nlm.nih.gov/pubmed/35869111
http://dx.doi.org/10.1038/s41467-022-31852-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307594/
https://www.ncbi.nlm.nih.gov/pubmed/35869111
http://dx.doi.org/10.1038/s41467-022-31852-w

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