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Assessing comparative importance of DNA sequence and epigenetic modifications on gene expression using a deep convolutional neural network

Gene expression is regulated at both transcriptional and post-transcriptional levels. DNA sequence and epigenetic modifications are key factors which regulate gene transcription. Understanding their complex interactions and their respective contributions to gene expression regulation remains a chall...

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Detalles Bibliográficos
Autores principales: Gao, Shang, Rehman, Jalees, Dai, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307602/
https://www.ncbi.nlm.nih.gov/pubmed/35891778
http://dx.doi.org/10.1016/j.csbj.2022.07.014