Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage

BRCA1 mutation is the genetic predisposition in causing genome instability towards cancer. BRCA1 mutation is predominantly germline inherited at the fertilization. However, when the inherited mutation initiates genome instability in the mutation carriers remains largely elusive. We used a heterozygo...

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Detalles Bibliográficos
Autores principales: Wu, Xiaobing, Guo, Maoni, Cui, Jian, Cai, Haoyang, Wang, San Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307611/
https://www.ncbi.nlm.nih.gov/pubmed/35869059
http://dx.doi.org/10.1038/s41389-022-00417-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307611/
https://www.ncbi.nlm.nih.gov/pubmed/35869059
http://dx.doi.org/10.1038/s41389-022-00417-3

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