Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity

Oncogenic mutations in metabolic genes and associated oncometabolite accumulation support cancer progression but can also restrict cellular functions needed to cope with DNA damage. For example, gain-of-function mutations in isocitrate dehydrogenase (IDH) and the resulting accumulation of the oncome...

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Detalles Bibliográficos
Autores principales: Xiang, Kexu, Kalthoff, Christian, Münch, Corinna, Jendrossek, Verena, Matschke, Johann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307853/
https://www.ncbi.nlm.nih.gov/pubmed/35869047
http://dx.doi.org/10.1038/s41419-022-05098-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307853/
https://www.ncbi.nlm.nih.gov/pubmed/35869047
http://dx.doi.org/10.1038/s41419-022-05098-9

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