The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors

Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the tumor microenvironment (TME) that suppress their anti-tumor activity. Toxic metabolites, such as lactate and ketone bodies, are produced mainly by catabolic cancer-associated fibroblasts (CAFs) to feed anabolic...

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Detalles Bibliográficos
Autores principales: Mostafavi, Samaneh, Zalpoor, Hamidreza, Hassan, Zuhair Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308248/
https://www.ncbi.nlm.nih.gov/pubmed/35869449
http://dx.doi.org/10.1186/s11658-022-00356-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308248/
https://www.ncbi.nlm.nih.gov/pubmed/35869449
http://dx.doi.org/10.1186/s11658-022-00356-2

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