First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement

Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the 11 zinc‐dependent HDACs, HDAC10 has received relatively little attention by drug di...

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Detalles Bibliográficos
Autores principales: Herp, Daniel, Ridinger, Johannes, Robaa, Dina, Shinsky, Stephen A., Schmidtkunz, Karin, Yesiloglu, Talha Z., Bayer, Theresa, Steimbach, Raphael R., Herbst‐Gervasoni, Corey J., Merz, Annika, Romier, Christophe, Sehr, Peter, Gunkel, Nikolas, Miller, Aubry K., Christianson, David W., Oehme, Ina, Sippl, Wolfgang, Jung, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308754/
https://www.ncbi.nlm.nih.gov/pubmed/35608330
http://dx.doi.org/10.1002/cbic.202200180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308754/
https://www.ncbi.nlm.nih.gov/pubmed/35608330
http://dx.doi.org/10.1002/cbic.202200180

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