Cargando…

Human iPSC co-culture model to investigate the interaction between microglia and motor neurons

Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by motor neuron degeneration with additional involvement of non-neuronal cells, in particular, microglia. In previous work, we have established protocols for the differentiation of iPSC-derived spinal motor neuro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vahsen, Björn F., Gray, Elizabeth, Candalija, Ana, Cramb, Kaitlyn M. L., Scaber, Jakub, Dafinca, Ruxandra, Katsikoudi, Antigoni, Xu, Yinyan, Farrimond, Lucy, Wade-Martins, Richard, James, William S., Turner, Martin R., Cowley, Sally A., Talbot, Kevin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308778/ https://www.ncbi.nlm.nih.gov/pubmed/35871163 http://dx.doi.org/10.1038/s41598-022-16896-8

Ejemplares similares

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
por: Vahsen, Björn F., et al.
Publicado: (2023)

Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD
por: Dafinca, Ruxandra, et al.
Publicado: (2020)

Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models
por: Hedegaard, Anne, et al.
Publicado: (2020)

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
por: Beccano-Kelly, Dayne A., et al.
Publicado: (2023)

iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson’s Disease
por: Badanjak, Katja, et al.
Publicado: (2021)

Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia
por: Washer, Sam J., et al.
Publicado: (2022)

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages
por: Haenseler, Walther, et al.
Publicado: (2017)

Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia
por: Reich, Marvin, et al.
Publicado: (2021)

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres
por: Abreu, Celina Monteiro, et al.
Publicado: (2018)

Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons
por: Allison, Reilly L., et al.
Publicado: (2022)

C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell‐Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
por: Dafinca, Ruxandra, et al.
Publicado: (2016)

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
por: Bassil, Reina, et al.
Publicado: (2021)

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia
por: Stöberl, Nina, et al.
Publicado: (2023)

Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening
por: Gutbier, Simon, et al.
Publicado: (2020)

Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
por: Xu, Ranjie, et al.
Publicado: (2020)

iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer’s Disease
por: Ihnatovych, Ivanna, et al.
Publicado: (2020)

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states
por: Dräger, Nina M., et al.
Publicado: (2022)

iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice
por: Niu, Xinyu, et al.
Publicado: (2023)

Generation of iPSC-based human-mouse microglial brain chimeras to study senescence of human microglia
por: Jin, Mengmeng, et al.
Publicado: (2022)

Proteomics and phosphoproteomics profiling in glutamatergic neurons and microglia in an iPSC model of Jansen de Vries Syndrome
por: Aguilan, Jennifer T., et al.
Publicado: (2023)

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons
por: Beevers, Joel E., et al.
Publicado: (2017)

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
por: Zambon, Federico, et al.
Publicado: (2019)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

iPSC Bioprinting: Where are We at?
por: Romanazzo, Sara, et al.
Publicado: (2019)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

iPSC for modeling neurodegenerative disorders
por: Valadez-Barba, Valeria, et al.
Publicado: (2020)

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia
por: Jairaman, Amit, et al.
Publicado: (2022)

Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia
por: Wißfeld, Jannis, et al.
Publicado: (2021)

Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells
por: Schmidt, Sissel Ida, et al.
Publicado: (2021)

Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia
por: Kenkhuis, Boyd, et al.
Publicado: (2022)

Reenacting Neuroectodermal Exposure of Hematopoietic Progenitors Enables Scalable Production of Cryopreservable iPSC-Derived Human Microglia
por: Mathews, Mona, et al.
Publicado: (2022)

Assessing human iPSC-derived microglia identity and function by immunostaining, phagocytosis, calcium activity, and inflammation assay
por: Hübschmann, Verena, et al.
Publicado: (2022)

Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism
por: Okarmus, Justyna, et al.
Publicado: (2021)

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
por: Hedegaard, Anne, et al.
Publicado: (2020)

Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages
por: Navarro-Guerrero, Elena, et al.
Publicado: (2021)

Robust detection of undifferentiated iPSC among differentiated cells
por: Sekine, Keisuke, et al.
Publicado: (2020)

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
por: Fernandes, Hugo J.R., et al.
Publicado: (2016)

Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release
por: Burley, Sarah, et al.
Publicado: (2022)

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
por: Dolan, Michael-John, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_h8tdplmooqvltbpv7rkelkf7g6