Cargando…

Exosomal circPABPC1 promotes colorectal cancer liver metastases by regulating HMGA2 in the nucleus and BMP4/ADAM19 in the cytoplasm

Liver metastasis is the leading cause of death in colorectal carcinoma (CRC). However, little is known about the mechanisms of transferring effector messages between the primary tumor and the site of metastasis. Exosomes provide a novel transfer message method, and exosomal circular RNAs (circRNAs)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yang, Hu, Jialei, Wang, Meng, Yuan, Yihang, Zhou, Fangyuan, Zhao, Haosen, Qiu, Tianming, Liang, Leilei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308786/ https://www.ncbi.nlm.nih.gov/pubmed/35871166 http://dx.doi.org/10.1038/s41420-022-01124-z

Ejemplares similares

Effect and mechanism of circHMGA2 on ferroptosis and pyroptosis in myocardial ischemia-reperfusion model CircHMGA2 exacerbates MI/R injury
por: Feng, Pin, et al.
Publicado: (2023)

N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
por: Chen, Ri-Xin, et al.
Publicado: (2019)

Functional implications of PABPC1 in the development of ovarian cancer
por: Feng, Cong, et al.
Publicado: (2021)

Cytoplasmic poly(A)-binding protein 1 (PABPC1) is a prognostic biomarker to predict survival in nasopharyngeal carcinoma regardless of chemoradiotherapy
por: Feng, Ling, et al.
Publicado: (2023)

PABPC1——mRNA stability, protein translation and tumorigenesis
por: Qi, Ya, et al.
Publicado: (2022)

Correction: Cytoplasmic poly(A)-binding protein 1 (PABPC1) is a prognostic biomarker to predict survival in nasopharyngeal carcinoma regardless of chemoradiotherapy
por: Ling, Feng, et al.
Publicado: (2023)

The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus
por: Zhu, Hongjia, et al.
Publicado: (2022)

High-Expression of Cytoplasmic Poly (A) Binding Protein 1 (PABPC1) as a Prognostic Biomarker for Early-Stage Esophageal Squamous Cell Carcinoma
por: Pu, Jiangtao, et al.
Publicado: (2021)

Prognostic significance of high mobility group A2 (HMGA2) in pancreatic ductal adenocarcinoma: malignant functions of cytoplasmic HMGA2 expression
por: Gundlach, Jan-Paul, et al.
Publicado: (2021)

A NUCLEUS WITH CYTOPLASMIC FEATURES
por: Bloom, Gunnar D.
Publicado: (1967)

Née de la c{circ}ote d'Adam /
por: Farah, Nuruddin, 1945-
Publicado: (1987)

The ADAM15 ectodomain is shed from secretory exosomes
por: Lee, Hee Doo, et al.
Publicado: (2015)

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10
por: Janes, Peter W., et al.
Publicado: (2009)

ADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity
por: e Costa, Rute A.P., et al.
Publicado: (2020)

Poly(A) tail length regulates PABPC1 expression to tune translation in the heart
por: Chorghade, Sandip, et al.
Publicado: (2017)

Exosomes as drug delivery system in gastrointestinal cancer
por: Xie, Fangyuan, et al.
Publicado: (2023)

Seneca Valley Virus 3C(pro) Cleaves PABPC1 to Promote Viral Replication
por: Xue, Qiao, et al.
Publicado: (2020)

PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy
por: Jiao, Yajuan, et al.
Publicado: (2021)

ADAM11 a novel regulator of Wnt and BMP4 signaling in neural crest and cancer
por: Pandey, Ankit, et al.
Publicado: (2023)

CircRNA hsa_circ_0005909 Promotes Cell Proliferation of Osteosarcoma Cells by Targeting miR-338-3p/HMGA1 Axis
por: Zhang, Cailong, et al.
Publicado: (2021)

Targeting of the cytosolic poly(A) binding protein PABPC1 to mitochondria causes mitochondrial translation inhibition
por: Wydro, Mateusz, et al.
Publicado: (2010)

Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations
por: Peixeiro, Isabel, et al.
Publicado: (2012)

Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy
por: Fan, Guangming, et al.
Publicado: (2019)

Bi‐allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility
por: Wang, Weijie, et al.
Publicado: (2023)

Coupling of the nucleus and cytoplasm: role of the LINC complex
por: Crisp, Melissa, et al.
Publicado: (2006)

Quality control of cytoplasmic proteins inside the nucleus
por: Borgert, Lion, et al.
Publicado: (2022)

Circ_0109046 Promotes the Progression of Endometrial Cancer via Regulating miR-136/HMGA2 Axis
por: Shi, Yanping, et al.
Publicado: (2020)

m6A modification of circHPS5 and hepatocellular carcinoma progression through HMGA2 expression
por: Rong, Dawei, et al.
Publicado: (2021)

PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p
por: Zhang, Ying, et al.
Publicado: (2022)

Exosome-Derived ADAM17 Promotes Liver Metastasis in Colorectal Cancer
por: Sun, Jinbing, et al.
Publicado: (2021)

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
por: Huntzinger, Eric, et al.
Publicado: (2010)

BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
por: Stupfler, Benjamin, et al.
Publicado: (2016)

Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis
por: KASHIWABARA, Shin-ichi, et al.
Publicado: (2016)

PABPC1 promotes cell proliferation and metastasis in pancreatic adenocarcinoma by regulating COL12A1 expression
por: Yao, Weijie, et al.
Publicado: (2023)

Circ_0067835 sponges miR‐324‐5p to induce HMGA1 expression in endometrial carcinoma cells
por: Liu, Yun, et al.
Publicado: (2020)

circUBAP2 regulates osteosarcoma progression via the miR-204-3p/HMGA2 axis
por: Ma, Weiguo, et al.
Publicado: (2021)

Differences between nucleus and cytoplasm in the degree of actin polymerization
Publicado: (1978)

Mitotic architecture of the cell: the filament networks of the nucleus and cytoplasm
Publicado: (1983)

Translational Diffusion of Macromolecule-sized Solutes in Cytoplasm and Nucleus
por: Seksek, Olivier, et al.
Publicado: (1997)

Distribution of proteins between nucleus and cytoplasm of amoeba proteus
por: Goldstein, L, et al.
Publicado: (1981)

Cannot write session to /tmp/vufind_sessions/sess_q280s8ohi87em6kodtdi4nm2gp