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Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α

Doxorubicin (DOX)-based chemotherapy is widely used to treat malignant tumors; however, the cardiotoxicity induced by DOX restricts its clinical usage. A therapeutic dose of DOX can activate ubiquitin-proteasome system. However, whether and how ubiquitin-proteasome system brings out DOX-induced card...

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Detalles Bibliográficos
Autores principales: Shen, Yihui, Zhang, Hui, Ni, Yangyue, Wang, Xuejun, Chen, Yifan, Chen, Jiahui, Wang, Yan, Lin, Jinyi, Xu, Yuchen, Zhao, Jian-Yuan, Cheng, Leilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308790/
https://www.ncbi.nlm.nih.gov/pubmed/35871160
http://dx.doi.org/10.1038/s41419-022-05100-4