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Targeted gut microbiota manipulation attenuates seizures in a model of infantile spasms syndrome

Infantile spasms syndrome (IS) is a devastating early-onset epileptic encephalopathy associated with poor neurodevelopmental outcomes. When first-line treatment options, including adrenocorticotropic hormone and vigabatrin, are ineffective, the ketogenic diet (KD) is often employed to control seizur...

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Detalles Bibliográficos
Autores principales: Mu, Chunlong, Nikpoor, Naghmeh, Tompkins, Thomas A., Choudhary, Anamika, Wang, Melinda, Marks, Wendie N., Rho, Jong M., Scantlebury, Morris H., Shearer, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309045/
https://www.ncbi.nlm.nih.gov/pubmed/35730569
http://dx.doi.org/10.1172/jci.insight.158521