IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression

The ectonucleotidase CD39 functions as a checkpoint in purinergic signaling on effector T cells. By depleting eATP and initiating the generation of adenosine, it impairs memory cell development and contributes to T cell exhaustion, thereby causing defective tumor immunity and deficient T cell respon...

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Detalles Bibliográficos
Autores principales: Fang, Fengqin, Cao, Wenqiang, Mu, Yunmei, Okuyama, Hirohisa, Li, Lingjie, Qiu, Jingtao, Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309057/
https://www.ncbi.nlm.nih.gov/pubmed/35730568
http://dx.doi.org/10.1172/jci.insight.157509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309057/
https://www.ncbi.nlm.nih.gov/pubmed/35730568
http://dx.doi.org/10.1172/jci.insight.157509

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