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Immune landscape of a genetically engineered murine model of glioma compared with human glioma

Novel therapeutic strategies targeting glioblastoma (GBM) often fail in the clinic, partly because preclinical models in which hypotheses are being tested do not recapitulate human disease. To address this challenge, we took advantage of our previously developed spontaneous Qk/Trp53/Pten (QPP) tripl...

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Detalles Bibliográficos
Autores principales: Zamler, Daniel B., Shingu, Takashi, Kahn, Laura M., Huntoon, Kristin, Kassab, Cynthia, Ott, Martina, Tomczak, Katarzyna, Liu, Jintan, Li, Yating, Lai, Ivy, Zorilla-Veloz, Rocio, Yee, Cassian, Rai, Kunal, Kim, Betty Y.S., Watowich, Stephanie S., Heimberger, Amy B., Draetta, Giulio F., Hu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309065/
https://www.ncbi.nlm.nih.gov/pubmed/35653194
http://dx.doi.org/10.1172/jci.insight.148990