d-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione

Glutathione (GSH) is synthesized from three amino acids and the overall process is highly dependent on the availability of l-cysteine (l-Cys). GSH serves as an essential cofactor for glutathione peroxidase 4 (Gpx4), which reduces phospholipid hydroperoxides. The inactivation of Gpx4 or an insufficie...

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Detalles Bibliográficos
Autores principales: Homma, Takujiro, Osaki, Tsukasa, Kobayashi, Sho, Sato, Hideyo, Fujii, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309085/
https://www.ncbi.nlm.nih.gov/pubmed/35903611
http://dx.doi.org/10.3164/jcbn.21-143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309085/
https://www.ncbi.nlm.nih.gov/pubmed/35903611
http://dx.doi.org/10.3164/jcbn.21-143

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