Auxin-Inducible Degron System Reveals Temporal-Spatial Roles of HSF-1 and Its Transcriptional Program in Lifespan Assurance

HSF-1 is a key regulator of cellular proteotoxic stress response and is required for animal lifespan. In C. elegans, HSF-1 mediated heat shock response (HSR) declines sharply on the first day of adulthood, and HSF-1 was proposed to function primarily during larval stages for lifespan assurance based...

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Detalles Bibliográficos
Autores principales: Morphis, Allison C., Edwards, Stacey L., Erdenebat, Purevsuren, Kumar, Lalit, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309338/
https://www.ncbi.nlm.nih.gov/pubmed/35899092
http://dx.doi.org/10.3389/fragi.2022.899744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309338/
https://www.ncbi.nlm.nih.gov/pubmed/35899092
http://dx.doi.org/10.3389/fragi.2022.899744

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