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3-O-Sulfation induces sequence-specific compact topologies in heparan sulfate that encode a dynamic sulfation code

Heparan sulfate (HS) is arguably the most diverse linear biopolymer that is known to modulate hundreds of proteins. Whereas the configurational and conformational diversity of HS is well established in terms of varying sulfation patterns and iduronic acid (IdoA) puckers, a linear helical topology re...

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Detalles Bibliográficos
Autores principales: Holmes, Samuel G., Nagarajan, Balaji, Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309406/
https://www.ncbi.nlm.nih.gov/pubmed/35891779
http://dx.doi.org/10.1016/j.csbj.2022.07.013