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Evolutionary origin and functional diversification of aminotransferases

Aminotransferases (ATs) are pyridoxal 5′-phosphate–dependent enzymes that catalyze the transamination reactions between amino acid donor and keto acid acceptor substrates. Modern AT enzymes constitute ∼2% of all classified enzymatic activities, play central roles in nitrogen metabolism, and generate...

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Detalles Bibliográficos
Autores principales: Koper, Kaan, Han, Sang-Woo, Pastor, Delia Casas, Yoshikuni, Yasuo, Maeda, Hiroshi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309667/
https://www.ncbi.nlm.nih.gov/pubmed/35697072
http://dx.doi.org/10.1016/j.jbc.2022.102122