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When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy

Flare is the dominant feature of gout and occurs because of inflammatory response to monosodium urate crystals; prevention of gout flares should be the major goal of gout care. However, a paradoxical increase in the risk of flare following initiation of urate-lowering therapy presents considerable c...

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Detalles Bibliográficos
Autores principales: Choi, Hyon K., Zhang, Yuqing, Dalbeth, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309993/
https://www.ncbi.nlm.nih.gov/pubmed/35879610
http://dx.doi.org/10.1038/s41584-022-00804-5