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KMT2C-deficient tumors have elevated APOBEC mutagenesis and genomic instability in multiple cancers
The histone methyltransferase KMT2C is among the most frequently mutated epigenetic modifier genes in cancer and plays an essential role in MRE11-dependent DNA replication fork restart. However, the effects of KMT2C deficiency on genomic instability during tumorigenesis are unclear. Analyzing 9,663...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310081/ https://www.ncbi.nlm.nih.gov/pubmed/35898555 http://dx.doi.org/10.1093/narcan/zcac023 |