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KMT2C-deficient tumors have elevated APOBEC mutagenesis and genomic instability in multiple cancers

The histone methyltransferase KMT2C is among the most frequently mutated epigenetic modifier genes in cancer and plays an essential role in MRE11-dependent DNA replication fork restart. However, the effects of KMT2C deficiency on genomic instability during tumorigenesis are unclear. Analyzing 9,663...

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Detalles Bibliográficos
Autores principales:	Hu, Xiaoju, Biswas, Antara, De, Subhajyoti
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Cancer Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310081/ https://www.ncbi.nlm.nih.gov/pubmed/35898555 http://dx.doi.org/10.1093/narcan/zcac023

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