Multi-step screening of DNA/lipid nanoparticles and co-delivery with siRNA to enhance and prolong gene expression

Lipid nanoparticles hold great potential as an effective non-viral vector for nucleic acid-based gene therapy. Plasmid DNA delivery can result in extended transgene expression compared to mRNA-based technologies, yet there is a lack of systematic investigation into lipid nanoparticle compositions fo...

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Detalles Bibliográficos
Autores principales: Zhu, Yining, Shen, Ruochen, Vuong, Ivan, Reynolds, Rebekah A., Shears, Melanie J., Yao, Zhi-Cheng, Hu, Yizong, Cho, Won June, Kong, Jiayuan, Reddy, Sashank K., Murphy, Sean C., Mao, Hai-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310361/
https://www.ncbi.nlm.nih.gov/pubmed/35879315
http://dx.doi.org/10.1038/s41467-022-31993-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310361/
https://www.ncbi.nlm.nih.gov/pubmed/35879315
http://dx.doi.org/10.1038/s41467-022-31993-y

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