Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression

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The SARS-CoV-2 frameshifting element (FSE), a highly conserved mRNA region required for correct translation of viral polyproteins, defines an excellent therapeutic target against Covid-19. As discovered by our prior graph-theory analysis with SHAPE experiments, the FSE adopts a heterogeneous, length...

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Detalles Bibliográficos
Autores principales: Yan, Shuting, Zhu, Qiyao, Jain, Swati, Schlick, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310368/
https://www.ncbi.nlm.nih.gov/pubmed/35879278
http://dx.doi.org/10.1038/s41467-022-31353-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310368/
https://www.ncbi.nlm.nih.gov/pubmed/35879278
http://dx.doi.org/10.1038/s41467-022-31353-w

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