cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium

BACKGROUND: The degeneration of retinal pigmented epithelium (RPE) cells results in severe diseases, such as age-related macular degeneration (AMD) that causes blindness in millions of individuals. RESULTS: We report that targeting GMP-AMP (cGAMP) synthase (cGAS) alleviates Alu RNA-induced immune re...

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Detalles Bibliográficos
Autores principales: Li, Jing, Zhang, Feng, Bian, Wei, Chen, Yanyun, Liu, Jianying, Liu, Zhenyu, Xiong, Ying, Wan, Xiuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310409/
https://www.ncbi.nlm.nih.gov/pubmed/35879806
http://dx.doi.org/10.1186/s13578-022-00854-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310409/
https://www.ncbi.nlm.nih.gov/pubmed/35879806
http://dx.doi.org/10.1186/s13578-022-00854-y

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