Cargando…

cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium

BACKGROUND: The degeneration of retinal pigmented epithelium (RPE) cells results in severe diseases, such as age-related macular degeneration (AMD) that causes blindness in millions of individuals. RESULTS: We report that targeting GMP-AMP (cGAMP) synthase (cGAS) alleviates Alu RNA-induced immune re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jing, Zhang, Feng, Bian, Wei, Chen, Yanyun, Liu, Jianying, Liu, Zhenyu, Xiong, Ying, Wan, Xiuhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310409/ https://www.ncbi.nlm.nih.gov/pubmed/35879806 http://dx.doi.org/10.1186/s13578-022-00854-y

Ejemplares similares

Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity
por: Fukuda, Shinichi, et al.
Publicado: (2021)

Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities
por: Yamada, Kazuhisa, et al.
Publicado: (2020)

Translocation of the retinal pigment epithelium and formation of sub-retinal pigment epithelium deposit induced by subretinal deposit
por: Zhao, Lian, et al.
Publicado: (2007)

The Regulation of cGAS
por: Xiong, Meiguang, et al.
Publicado: (2018)

Evaluation of focal damage in the retinal pigment epithelium layer in serous retinal pigment epithelium detachment
por: Miura, Masahiro, et al.
Publicado: (2019)

Cytotoxicity and genotoxicity of bacterial magnetosomes against human retinal pigment epithelium cells
por: Qi, Lei, et al.
Publicado: (2016)

Setting Eyes on the Retinal Pigment Epithelium
por: Moreno-Marmol, Tania, et al.
Publicado: (2018)

Functions and Diseases of the Retinal Pigment Epithelium
por: Yang, Song, et al.
Publicado: (2021)

Lipofuscin Granule Bisretinoid Oxidation in the Human Retinal Pigment Epithelium forms Cytotoxic Carbonyls
por: Yakovleva, Marina, et al.
Publicado: (2021)

Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epithelium
por: Zhang, Youwen, et al.
Publicado: (2010)

Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models
por: Sugita, Sunao, et al.
Publicado: (2017)

Impact of drusen and drusenoid retinal pigment epithelium elevation size and structure on the integrity of the retinal pigment epithelium layer
por: Schlanitz, Ferdinand, et al.
Publicado: (2019)

Common clinical features of unilateral retinal pigment epithelium dysgenesis and combined hamartoma of the retina and retinal pigment epithelium
por: Zhu, Zhe, et al.
Publicado: (2022)

Substance P Alleviates Retinal Pigment Epithelium Dysfunction Caused by High Glucose-Induced Stress
por: Lee, Dahyeon, et al.
Publicado: (2023)

The multifaceted functions of cGAS
por: Liu, Haipeng, et al.
Publicado: (2022)

Transcriptome Profiling of Embryonic Retinal Pigment Epithelium Reprogramming
por: Tangeman, Jared A., et al.
Publicado: (2021)

Components of the cytoskeleton in the retinal pigmented epithelium of the chick
Publicado: (1985)

Retinal Pigment Epithelium Derived Stem Cells
por: Hiscott, Paul, et al.
Publicado: (2009)

Characterization of the retinal pigment epithelium in Friedreich ataxia
por: Crombie, Duncan E., et al.
Publicado: (2015)

Retinal pigment epithelium changes in Kartagener syndrome
por: Garcia, Maria D., et al.
Publicado: (2018)

Simple Congenital Hamartoma of the Retinal Pigment Epithelium
por: Nakatsuka, Austin S., et al.
Publicado: (2020)

Circadian Regulation of Retinal Pigment Epithelium Function
por: Baba, Kenkichi, et al.
Publicado: (2022)

Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration
por: Zou, Ming, et al.
Publicado: (2022)

Modulation of Immune Responses by Extracellular Vesicles From Retinal Pigment Epithelium
por: Knickelbein, Jared E., et al.
Publicado: (2016)

Stem Cell Derived Retinal Pigment Epithelium: The Role of Pigmentation as Maturation Marker and Gene Expression Profile Comparison with Human Endogenous Retinal Pigment Epithelium.
por: Bennis, A., et al.
Publicado: (2017)

Reprogramming of the chick retinal pigmented epithelium after retinal injury
por: Luz-Madrigal, Agustin, et al.
Publicado: (2014)

Involvement of the Retinal Pigment Epithelium in the Development of Retinal Lattice Degeneration
por: Mizuno, Hiroshi, et al.
Publicado: (2020)

Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium
por: Sparrow, Janet R., et al.
Publicado: (2021)

Retinal Pigment Epithelium Remodeling in Mouse Models of Retinitis Pigmentosa
por: Napoli, Debora, et al.
Publicado: (2021)

Inhibition of cGAS–STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury
por: Wu, Xingdi, et al.
Publicado: (2023)

Nuclear cGAS: sequestration and beyond
por: Bai, Juli, et al.
Publicado: (2021)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability
por: Hong, Christy, et al.
Publicado: (2019)

Cancer-associated Nummular Loss of the Retinal Pigment Epithelium
por: Lee, Jun Mok, et al.
Publicado: (2007)

Localizations of visual cycle components in retinal pigment epithelium
por: Huang, Jing, et al.
Publicado: (2009)

Functional annotation of the human retinal pigment epithelium transcriptome
por: Booij, Judith C, et al.
Publicado: (2009)

Age-Related Changes in the Retinal Pigment Epithelium (RPE)
por: Gu, Xiaorong, et al.
Publicado: (2012)

Congenital hypertrophy of the retinal pigment epithelium in Gardner's syndrome
por: Laghmari, Mina, et al.
Publicado: (2014)

Infection of Human Retinal Pigment Epithelium with Chlamydia trachomatis
por: Boiko, Ernest, et al.
Publicado: (2015)

Bilateral multifocal retinal pigment epithelium detachment and pachychoroidopathy
por: Nagesha, Chokkahalli K, et al.
Publicado: (2018)

Proteomics of Human Retinal Pigment Epithelium (RPE) Cells
por: Beranova-Giorgianni, Sarka, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jmrgg0njneuuos5si24ll5oeb1