Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells

Polyamine dysregulation plays key roles in a broad range of human diseases from cancer to neurodegeneration. Snyder-Robinson syndrome (SRS) is the first known genetic disorder of the polyamine pathway, caused by X-linked recessive loss-of-function mutations in spermine synthase. In the Drosophila SR...

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Detalles Bibliográficos
Autores principales: Tao, Xianzun, Zhu, Yi, Diaz-Perez, Zoraida, Yu, Seok-Ho, Foley, Jackson R., Stewart, Tracy Murray, Casero, Robert A., Steet, Richard, Zhai, R. Grace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310527/
https://www.ncbi.nlm.nih.gov/pubmed/35801587
http://dx.doi.org/10.1172/jci.insight.158457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310527/
https://www.ncbi.nlm.nih.gov/pubmed/35801587
http://dx.doi.org/10.1172/jci.insight.158457

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