Selenocarbamates As a Prodrug‐Based Approach to Carbonic Anhydrase Inhibition

A study on the activity of selenocarbamates as a novel chemotype acting as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors is reported. Undergoing CA‐mediated hydrolysis, selenocarbamates release selenolates behaving as zinc binding groups and effectively inhibiting CAs. A series of selenocarbamates...

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Detalles Bibliográficos
Autores principales: Angeli, Andrea, Ferraroni, Marta, Capperucci, Antonella, Tanini, Damiano, Costantino, Gabriele, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310613/
https://www.ncbi.nlm.nih.gov/pubmed/35238480
http://dx.doi.org/10.1002/cmdc.202200085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310613/
https://www.ncbi.nlm.nih.gov/pubmed/35238480
http://dx.doi.org/10.1002/cmdc.202200085

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