IRF3 and IRF7 require SIRT1 for liquid–liquid phase separation and transactivation of IFN-1

Deacetylation of specific lysine residues in the DNA-binding domain of the transcription factors IRF3 and IRF7 by SIRT1 is necessary for liquid–liquid phase separation and transactivation of type I interferons. SIRT1 agonists partially restored the impaired innate immune responses in senescent cells...

Descripción completa

Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Research Briefing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310678/
https://www.ncbi.nlm.nih.gov/pubmed/35879453
http://dx.doi.org/10.1038/s41590-022-01270-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310678/
https://www.ncbi.nlm.nih.gov/pubmed/35879453
http://dx.doi.org/10.1038/s41590-022-01270-7

Ejemplares similares