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IRF3 and IRF7 require SIRT1 for liquid–liquid phase separation and transactivation of IFN-1
Deacetylation of specific lysine residues in the DNA-binding domain of the transcription factors IRF3 and IRF7 by SIRT1 is necessary for liquid–liquid phase separation and transactivation of type I interferons. SIRT1 agonists partially restored the impaired innate immune responses in senescent cells...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310678/ https://www.ncbi.nlm.nih.gov/pubmed/35879453 http://dx.doi.org/10.1038/s41590-022-01270-7 |