Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A(2A) Receptor with Preladenant Conjugates

The G protein‐coupled adenosine A(2A) receptor (A(2A)AR) is an important new (potential) drug target in immuno‐oncology, and for neurodegenerative diseases. Preladenant and its derivatives belong to the most potent A(2A)AR antagonists displaying exceptional selectivity. While crystal structures of t...

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Detalles Bibliográficos
Autores principales: Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310709/
https://www.ncbi.nlm.nih.gov/pubmed/35174942
http://dx.doi.org/10.1002/anie.202115545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310709/
https://www.ncbi.nlm.nih.gov/pubmed/35174942
http://dx.doi.org/10.1002/anie.202115545

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