XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA

Base excision repair (BER) removes damaged bases by generating single‐strand breaks (SSBs), gap‐filling by DNA polymerase β (POLβ), and resealing SSBs. A base‐damaging agent, methyl methanesulfonate (MMS) is widely used to study BER. BER increases cellular tolerance to MMS, anti‐cancer base‐damaging...

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Detalles Bibliográficos
Autores principales: Hirota, Kouji, Ooka, Masato, Shimizu, Naoto, Yamada, Kousei, Tsuda, Masataka, Ibrahim, Mahmoud Abdelghany, Yamada, Shintaro, Sasanuma, Hiroyuki, Masutani, Mitsuko, Takeda, Shunichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310723/
https://www.ncbi.nlm.nih.gov/pubmed/35194903
http://dx.doi.org/10.1111/gtc.12929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310723/
https://www.ncbi.nlm.nih.gov/pubmed/35194903
http://dx.doi.org/10.1111/gtc.12929

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