GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms

GPNMB (glycoprotein nonmetastatic B) and other TFE3/TFEB transcriptional targets have been proposed as markers for microphthalmia (MiT) translocation renal cell carcinomas (tRCCs). We recently demonstrated that constitutive mTORC1 activation via TSC1/2 loss leads to increased activity of TFE3/TFEB,...

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Detalles Bibliográficos
Autores principales: Salles, Daniela C, Asrani, Kaushal, Woo, Juhyung, Vidotto, Thiago, Liu, Hans B, Vidal, Igor, Matoso, Andres, Netto, George J, Argani, Pedram, Lotan, Tamara L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310781/
https://www.ncbi.nlm.nih.gov/pubmed/35072947
http://dx.doi.org/10.1002/path.5875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310781/
https://www.ncbi.nlm.nih.gov/pubmed/35072947
http://dx.doi.org/10.1002/path.5875

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