2‐Amino‐4‐aryl‐5‐oxo‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitriles with Microtubule‐Disruptive, Centrosome‐Declustering, and Antiangiogenic Effects in vitro and in vivo

A series of fifteen 2‐amino‐4‐aryl‐5‐oxo‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitriles (1 a–o) were synthesized via a three‐component reaction of 4‐hydroxycoumarin, malononitrile, and diversely substituted benzaldehydes or pyridine carbaldehydes. The compounds were tested for anticancer activitie...

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Detalles Bibliográficos
Autores principales: Köhler, Leonhard H. F., Reich, Sebastian, Begemann, Gerrit, Schobert, Rainer, Biersack, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311119/
https://www.ncbi.nlm.nih.gov/pubmed/35226402
http://dx.doi.org/10.1002/cmdc.202200064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311119/
https://www.ncbi.nlm.nih.gov/pubmed/35226402
http://dx.doi.org/10.1002/cmdc.202200064

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