Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor

OBJECTIVE: The formation of 24S‐hydroxycholesterol is a brain‐specific mechanism of cholesterol catabolism catalyzed by cholesterol 24‐hydroxylase (CYP46A1, also known as CH24H). CH24H has been implicated in various biological mechanisms, whereas pharmacological lowering of 24S‐hydroxycholesterol ha...

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Detalles Bibliográficos
Autores principales: Nishi, Toshiya, Metcalf, Cameron S., Fujimoto, Shinji, Hasegawa, Shigeo, Miyamoto, Maki, Sunahara, Eiji, Watanabe, Sayuri, Kondo, Shinichi, White, H. Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311151/
https://www.ncbi.nlm.nih.gov/pubmed/35316533
http://dx.doi.org/10.1111/epi.17232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311151/
https://www.ncbi.nlm.nih.gov/pubmed/35316533
http://dx.doi.org/10.1111/epi.17232

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