The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in Staphylococcus aureus

Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in S. aureus using fluctuation analysis at 4 × minimum inhibitory concentrati...

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Detalles Bibliográficos
Autores principales: Balansky, Jan, Pfarr, Kenneth, Szekat, Christiane, Kehraus, Stefan, Aden, Tilman, Grosse, Miriam, Jansen, Rolf, Hesterkamp, Thomas, Schiefer, Andrea, König, Gabriele M., Stadler, Marc, Hoerauf, Achim, Bierbaum, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311656/
https://www.ncbi.nlm.nih.gov/pubmed/35884174
http://dx.doi.org/10.3390/antibiotics11070920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311656/
https://www.ncbi.nlm.nih.gov/pubmed/35884174
http://dx.doi.org/10.3390/antibiotics11070920

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