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Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A

A total synthesis of the cyclic lipodepsipeptide natural product orfamide A was achieved. By developing a synthesis format using an aminoacid ester building block and SPPS protocol adaptation, a focused library of target compounds was obtained, in high yield and purity. Spectral and LC‐HRMS data of...

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Detalles Bibliográficos
Autores principales: Bando, Yuko, Hou, Yu, Seyfarth, Lydia, Probst, Jannik, Götze, Sebastian, Bogacz, Marta, Hellmich, Ute A., Stallforth, Pierre, Mittag, Maria, Arndt, Hans‐Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311703/
https://www.ncbi.nlm.nih.gov/pubmed/35199896
http://dx.doi.org/10.1002/chem.202104417