Fetal glucocorticoid exposure leads to sex‐specific changes in drug‐transporter function at the blood‐brain barrier in juvenile guinea pigs

Antenatal synthetic glucocorticoids (sGCs) are a life‐saving treatment in managing pre‐term birth. However, off‐target effects of sGCs can impact blood‐brain barrier (BBB) drug transporters essential for fetal brain protection, including P‐glycoprotein (P‐gp/Abcb1) and breast cancer resistance prote...

Descripción completa

Detalles Bibliográficos
Autores principales: Eng, Margaret Elizabeth, Bloise, Enrrico, Matthews, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311705/
https://www.ncbi.nlm.nih.gov/pubmed/35262963
http://dx.doi.org/10.1096/fj.202101552RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311705/
https://www.ncbi.nlm.nih.gov/pubmed/35262963
http://dx.doi.org/10.1096/fj.202101552RR

Ejemplares similares