Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles

KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1. Loss of KEAP1 leads to an accumulation of protein ubiquitin aggregates and defective autophagy. To be...

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Detalles Bibliográficos
Autores principales: Uribe-Carretero, Elisabet, Martinez-Chacón, Guadalupe, Yakhine-Diop, Sokhna M. S., Duque-González, Gema, Rodríguez-Arribas, Mario, Alegre-Cortés, Eva, Paredes-Barquero, Marta, Canales-Cortés, Saray, Pizarro-Estrella, Elisa, Cuadrado, Antonio, González-Polo, Rosa Ana, Fuentes, José M., Niso-Santano, Mireia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311848/
https://www.ncbi.nlm.nih.gov/pubmed/35883891
http://dx.doi.org/10.3390/antiox11071398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311848/
https://www.ncbi.nlm.nih.gov/pubmed/35883891
http://dx.doi.org/10.3390/antiox11071398

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