Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach

Akt is a protein kinase that has been implicated in the progression of cancerous tumours. A number of covalent allosteric Akt inhibitors are known, and based on these scaffolds, a small library of novel potential covalent allosteric imidazopyridine‐based inhibitors was designed. The envisaged compou...

Descripción completa

Detalles Bibliográficos
Autores principales: van der Westhuizen, Leandi, Weisner, Jörn, Taher, Abu, Landel, Ina, Quambusch, Lena, Lindemann, Marius, Uhlenbrock, Niklas, Müller, Matthias P., Green, Ivan R., Pelly, Stephen C., Rauh, Daniel, van Otterlo, Willem A. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311865/
https://www.ncbi.nlm.nih.gov/pubmed/35170857
http://dx.doi.org/10.1002/cmdc.202100776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311865/
https://www.ncbi.nlm.nih.gov/pubmed/35170857
http://dx.doi.org/10.1002/cmdc.202100776

Ejemplares similares