A New Serum Macrophage Checkpoint Biomarker for Innate Immunotherapy: Soluble Signal-Regulatory Protein Alpha (sSIRPα)

Background and Aims: The macrophage “don’t eat me” pathway CD47/SIRPα is a target for promising new immunotherapy. We hypothesized that a soluble variant of SIRPα is present in the blood and may function as a biomarker. Methods: Monocyte derived macrophages (MDMs) from human buffy-coats were stimula...

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Detalles Bibliográficos
Autores principales: Vladimirova, Yoanna V., Mølmer, Marie K., Antonsen, Kristian W., Møller, Niels, Rittig, Nikolaj, Nielsen, Marlene C., Møller, Holger J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312483/
https://www.ncbi.nlm.nih.gov/pubmed/35883493
http://dx.doi.org/10.3390/biom12070937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312483/
https://www.ncbi.nlm.nih.gov/pubmed/35883493
http://dx.doi.org/10.3390/biom12070937

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