High Energy Channeling and Malleable Transition States: Molecular Dynamics Simulations and Free Energy Landscapes for the Thermal Unfolding of Protein U1A and 13 Mutants

The spliceosome protein U1A is a prototype case of the RNA recognition motif (RRM) ubiquitous in biological systems. The in vitro kinetics of the chemical denaturation of U1A indicate that the unfolding of U1A is a two-state process but takes place via high energy channeling and a malleable transiti...

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Detalles Bibliográficos
Autores principales: Dang, Na Le, Baranger, Anne M., Beveridge, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312810/
https://www.ncbi.nlm.nih.gov/pubmed/35883496
http://dx.doi.org/10.3390/biom12070940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312810/
https://www.ncbi.nlm.nih.gov/pubmed/35883496
http://dx.doi.org/10.3390/biom12070940

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