Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry

Background: Atrial fibroblasts activation causes atrial fibrosis, which is one major pathophysiological contributor to atrial fibrillation (AF) genesis. Klotho is a pleiotropic protein with remarkable cardiovascular effects, including anti-inflammatory, anti-oxidative, and anti-apoptotic effects. Th...

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Detalles Bibliográficos
Autores principales: Hung, Yuan, Chung, Cheng-Chih, Chen, Yao-Chang, Kao, Yu-Hsun, Lin, Wei-Shiang, Chen, Shih-Ann, Chen, Yi-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312905/
https://www.ncbi.nlm.nih.gov/pubmed/35884879
http://dx.doi.org/10.3390/biomedicines10071574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312905/
https://www.ncbi.nlm.nih.gov/pubmed/35884879
http://dx.doi.org/10.3390/biomedicines10071574

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