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TIRAP/Mal Positively Regulates TLR8-Mediated Signaling via IRF5 in Human Cells

Toll-like receptor 8 (TLR8) recognizes single-stranded RNA of viral and bacterial origin as well as mediates the secretion of pro-inflammatory cytokines and type I interferons by human monocytes and macrophages. TLR8, as other endosomal TLRs, utilizes the MyD88 adaptor protein for initiation of sign...

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Detalles Bibliográficos
Autores principales:	Nilsen, Kaja Elisabeth, Skjesol, Astrid, Frengen Kojen, June, Espevik, Terje, Stenvik, Jørgen, Yurchenko, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312982/ https://www.ncbi.nlm.nih.gov/pubmed/35884781 http://dx.doi.org/10.3390/biomedicines10071476

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