CoCl(2)-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors

Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidative stress and induce dysfunction in ECs. Our work...

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Detalles Bibliográficos
Autores principales: Kutryb-Zajac, Barbara, Kawecka, Ada, Braczko, Alicja, Franczak, Marika, Slominska, Ewa M., Giovannoni, Roberto, Smolenski, Ryszard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313011/
https://www.ncbi.nlm.nih.gov/pubmed/35884844
http://dx.doi.org/10.3390/biomedicines10071540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313011/
https://www.ncbi.nlm.nih.gov/pubmed/35884844
http://dx.doi.org/10.3390/biomedicines10071540

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