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The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury

Pyroptosis is a process of programmed cell death mediated by gasdermin (GSDM) found in recent years. In the process of pyroptosis, caspase-1 or caspase-11/4/5 is activated, which cleaves gasdermin D and separates its N-terminal pore-forming domain (PFD). The oligomers of PFD bind to the cell membran...

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Autores principales: Zhao, Huijie, Yang, Yihan, Si, Xinya, Liu, Huiyang, Wang, Honggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313059/
https://www.ncbi.nlm.nih.gov/pubmed/35883566
http://dx.doi.org/10.3390/biom12071010
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author Zhao, Huijie
Yang, Yihan
Si, Xinya
Liu, Huiyang
Wang, Honggang
author_facet Zhao, Huijie
Yang, Yihan
Si, Xinya
Liu, Huiyang
Wang, Honggang
author_sort Zhao, Huijie
collection PubMed
description Pyroptosis is a process of programmed cell death mediated by gasdermin (GSDM) found in recent years. In the process of pyroptosis, caspase-1 or caspase-11/4/5 is activated, which cleaves gasdermin D and separates its N-terminal pore-forming domain (PFD). The oligomers of PFD bind to the cell membrane and form macropores on the membrane, resulting in cell swelling and membrane rupture. Increasing evidence indicates that pyroptosis is involved in many diseases, including ischemia reperfusion injury. Autophagy is a highly conserved catabolic process in eukaryotic cells. It plays an important role in the survival and maintenance of cells by degrading organelles, proteins, and macromolecules in the cytoplasm and recycling degradation products. Increasing evidence shows that dysfunctional autophagy participates in many diseases. Recently, autophagy and pyroptosis have been reported to play a vital role in the process of ischemia/reperfusion injury, but the related mechanisms are not completely clear. Therefore, this article reviews the role of autophagy and pyroptosis in ischemia–reperfusion injury and analyzes the related mechanisms to provide a basis for future research.
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spelling pubmed-93130592022-07-26 The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury Zhao, Huijie Yang, Yihan Si, Xinya Liu, Huiyang Wang, Honggang Biomolecules Review Pyroptosis is a process of programmed cell death mediated by gasdermin (GSDM) found in recent years. In the process of pyroptosis, caspase-1 or caspase-11/4/5 is activated, which cleaves gasdermin D and separates its N-terminal pore-forming domain (PFD). The oligomers of PFD bind to the cell membrane and form macropores on the membrane, resulting in cell swelling and membrane rupture. Increasing evidence indicates that pyroptosis is involved in many diseases, including ischemia reperfusion injury. Autophagy is a highly conserved catabolic process in eukaryotic cells. It plays an important role in the survival and maintenance of cells by degrading organelles, proteins, and macromolecules in the cytoplasm and recycling degradation products. Increasing evidence shows that dysfunctional autophagy participates in many diseases. Recently, autophagy and pyroptosis have been reported to play a vital role in the process of ischemia/reperfusion injury, but the related mechanisms are not completely clear. Therefore, this article reviews the role of autophagy and pyroptosis in ischemia–reperfusion injury and analyzes the related mechanisms to provide a basis for future research. MDPI 2022-07-21 /pmc/articles/PMC9313059/ /pubmed/35883566 http://dx.doi.org/10.3390/biom12071010 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Huijie
Yang, Yihan
Si, Xinya
Liu, Huiyang
Wang, Honggang
The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury
title The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury
title_full The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury
title_fullStr The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury
title_full_unstemmed The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury
title_short The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury
title_sort role of pyroptosis and autophagy in ischemia reperfusion injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313059/
https://www.ncbi.nlm.nih.gov/pubmed/35883566
http://dx.doi.org/10.3390/biom12071010
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