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α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications
α-Synuclein (αS) is remarkable for both its extensive conformational plasticity and pathologic prion-like properties. Physiologically, αS may populate disordered monomeric, helically folded tetrameric, or membrane-bound oligomeric states. Pathologically, αS may assemble into toxic oligomers and subs...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313095/ https://www.ncbi.nlm.nih.gov/pubmed/35883550 http://dx.doi.org/10.3390/biom12070994 |